Whereas the role of FKBP51 in preventing Paget’s disease of bone appears to be independent of autophagy regulation, the ability of the FKBP51-PHLPP-AKT-BECN1 complex to induce autophagy is determinant of outcome in other settings including antidepressant treatment efficacy and coronavirus infection [21,22,48]. This evidence concerns the gene PHLPP1 and Paget disease.