PNPLA3 and fibrosis: Most importantly, we additionally evaluated whether addition of the respective genetic markers improved diagnostic accuracy for well-known non-invasive fibrosis scores such as FIB-4 or the NAFLD Fibrosis score (NFS) and could show that addition of PNPLA3 improved accuracy of only the NFS but not FIB-4 (Supplemental Figure S5 and S6).