We uncovered that knock-down of this lncRNA significantly reduced the protein level of TLR4 and NF-κB p65 subunit, while its overexpression showed opposite effect, indicating that Linc-KIAA1737–2 might facilitate LPS-induced HK-2 cell apoptosis as well as sepsis-induced acute kidney injury by upregulating the protein levels of TLR4 and NF-κB p65 subunit. This evidence concerns the gene TLR4 and acute kidney injury.