NFKB1 and acute kidney injury: Later in 2016, Chun-Mei et al. compared the landscape of lncRNA expression in serum between sepsis induced acute kidney injury patients and healthy counterparts; by mapping the predicted target genes of miRNAs presumably regulated by the differentially expressed LncRNAs to Kegg pathways, they proposed that lncRNA might participate in the development of sepsis-induced acute kidney injury by regulating the MAPK, PI3K-Akt, TGF-beta and NF-κB signaling pathways that were involved in the immune and inflammatory responses (Chun-Mei et al. 2016).