We identified that Linc-KIAA1737–2 could be upregulated in HK-2 human proximal tubular epithelial cells by LPS treatment; knock-down of this lncRNA significantly attenuated LPS-induced apoptosis in HK-2 cells, while its overexpression showed opposite effect, suggesting the participation of this lncRNA in sepsis-induced acute kidney injury. Here, CIPC is linked to acute kidney injury.