For example, a rare haplotype of ROBO1 was found to cosegregate with dyslexia status in the majority of affected relatives of a large family, and the same gene was disrupted by a translocation in an unrelated case (Hannula-Jouppi et al. 2005); also, DYX1C1 was identified as a potential candidate because of a chromosomal rearrangement that cosegregated with dyslexia in multiple members of one family (Taipale et al. 2003). This evidence concerns the gene DNAAF4 and dyslexia.