The recent discovery of the identity ofthe σ2R rationalizes the search for small moleculeswith potential neuroprotective,29 antinociceptive,30 and antiproliferative effects.31 Concerningthe role of σ2Rs in the context of cancer, differentpharmacological studies have proved that the σ2Ris overexpressed in cancer cells, and its abundance is correlatedwith the proliferative status of certain tumors.32 Furthermore, in addition to the diagnostic imaging application,σ2R ligands have shown cytotoxic effects in tumorcells in vitro and in vivo. Here, TMEM97 is linked to cancer.