Interestingly, CM572 showed a dose-dependentcalcium response in a neuroblastoma cancer cell line (SK-N-SH) athigher doses, supporting its partial agonist properties at the σ2R. Subsequently, the cytotoxicity of CM572 was evaluated againstthree different cancer cell lines (i.e., SK-N-SH, PANC-1, and MCF-7)as well as toward normal cells such as primary epidermal melanocytesand human mammary epithelial cells. This evidence concerns the gene TMEM97 and cancer.