Once the SHH ligand bind to Ptch1, the inhibition of Smo by Ptch is relieved, and then facilitates the post‐translational process of the transcription factor GLI, which are closely related to cancer cell survival, cell growth, and epithelial‐mesenchymal transition (EMT) through regulating expressions of downstream target genes.9, 10. Here, SHH is linked to cancer.