To determine whether the SHH signaling pathway is involved in the tumorigenesis and development of ovarian cancer, immunohistochemistry (IHC) was performed to identify the positive expressions of SHH and SQSTM1, a marker of autophagy inhibition28 in borderline ovarian tumor tissues, epithelial ovarian cancer (EOC) tissues and benign ovarian tumor tissues. This evidence concerns the gene SHH and ovarian cancer.