Lo Ré et al. showed that autophagy is induced by GLI3, a well‐known nuclear executor of the SHH pathway, which regulated the expression and promoter activity of VMP1(Lo,39 Wang et al. found that in HCC cells, suppression of the SHH pathway promoted autophagy through up‐regulating the expression of Bnip3.25 This evidence concerns the gene SHH and hepatocellular carcinoma.