We have previously shown that asfotase alfa binds to the sites of ectopic calcification in the TNAP overexpression‐induced vascular calcification mouse models (Tagln‐Cre and Tie2‐Cre).(73) Therefore, we cannot rule out the possibility that the continuous administration of TNAP‐D10, either subcutaneously or as a gene therapy, may lead to the development or aggravation of ectopic calcification in some HPP patients. The gene discussed is TEK; the disease is hypophosphatasia.