ALPL and hypophosphatasia: First, the skeletal growth of treated female Alpl−/− mice was not as well corrected as in male Alpl−/− mice, which suggests the possibility of sex differences in response to AAV8‐TNAP‐D10; however, there are no established sex differences among patients with HPP,(3) and most previous in vivo studies did not indicate the sex differences in Alpl−/− mice.