More recently, a therapeutic gene approach combining two genes (fibroblast growth factor-2 (FGF-2) and soluble transforming growth factor-β-2 (sTGFβ2)) simultaneously in an AAV8 vector limits both obesity and type-2 diabetes phenotypes, and has separately been shown to improve cardiac contraction induced by aortic constriction [88]. This evidence concerns the gene FGF2 and obesity due to melanocortin 4 receptor deficiency.