In preclinical animal models of both type-1 and type-2 diabetes, a reduction in the expression and activity of the Ca2+ handling protein, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA2a), and/or an increase in its regulator, phospholamban (Pln), impairs cardiac function [12]. Here, PLN is linked to type 2 diabetes mellitus.