Receptor-interactingprotein 1 (RIP1) and receptor-interacting protein 3 (RIP3) can activate thesignaling cascade under the stimulus of the death signal and cause cell necrosis.This finding is supported by necrostain-1 (NEC-1), a specific inhibitor of RIP112,13.Necroptosis is common in ischemia-reperfusion injury and may be an effectivemechanism of ischemia-reperfusion injury14,15. The gene discussed is RIPK3; the disease is ischemia.