AR and cancer: Indeed, alterations in the expression of specific isoforms of certain genes and of splicing factors themselves can promote cell proliferation (e.g., androgen receptor [AR]; Liu et al., 2014), metastasis (e.g., CD44; Todaro et al., 2014; Xu et al., 2014), or avoid apoptosis (Dewaele et al., 2016; Schwerk and Schulze-Osthoff, 2005) in cancer.