METTL3 and acute myeloid leukemia: However, in a study of acute myeloid leukaemia, METTL3 was found to be necessary for the growth of acute myeloid leukaemia cells and down‐regulation of METTL3 could lead to cell cycle arrest, leukaemia cell differentiation, and even unable to induce leukaemia in immunodeficient mice.22, 23