Lee et al. concluded that defects in DNA methylation and genomic imprinting may have as well a contributory role to the pathomechanism of Ogden syndrome, showing that the Ser37Pro variant disrupts ICR binding of Naa10 and Dnmt1 (Lee et al., 2018a). This evidence concerns the gene NAA10 and Premature aging appearance-developmental delay-cardiac arrhythmia syndrome.