Re-analysis of the generated WES data within the SOLVE-RD consortium revealed one ClinVar-reported missense variant in PIK3CA (NM_006218.4; c.3140A>G; p.(His1047Arg)), a gene associated with somatic overgrowth syndromes, but not previously associated with gastric cancer [12, 13]. The gene discussed is PIK3CA; the disease is gastric cancer.