We also observed the activation of these proteins in healthy CD8+ T cells stimulated with cytokines, and validated these findings in KAI3 NK cells overexpressing GOF STAT3 mutations, indicating that enhanced p-STAT3 may promote LGLL pathogenesis in part via induction of these oncogenic pathways by cytokine stimuli. Here, CD8A is linked to T-cell large granular lymphocyte leukemia.