To further investigate whether STAT3Y640F mutation can upregulate epigenetic regulators, we used KAI3 NK cells previously engineered to overexpress exogenous STAT3 wildtype (STAT3WT) and hyperactive STAT3 variant (STAT3Y640F) [20] found in T-LGLL patients [3–5]. The gene discussed is STAT3; the disease is T-cell large granular lymphocyte leukemia.