Ern2−/− mice show increased sensitivity to DSS colitis.14 While the extent of inflammation is similar in WT and Ern2 deficient animals, loss of IRE1β results in an earlier onset, impaired recovery, and increased mortality following injury.15 This could be due to defects in goblet cells and/or mucus function in Ern2−/−. The gene discussed is ERN2; the disease is colitis.