As p62 and TDP-43 often co-localise with ubiquitin in ALS and FTLD tissue, and p62 recognises ubiquitinated proteins via its ubiquitin-associated (UBA) domain, we investigated whether nuclear mislocalisation of TDP-43 was dependent on the UBA domain. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.