To further examine whether ACLY and IGF1R participated in HOXA13-induced CRC invasion and metastasis, we downregulated the expression of ACLY and IGF1R in SW480-HOXA13 cells, and upregulated the expression of these genes in SW620-shHOXA13 cells (Fig. 2H). The gene discussed is IGF1R; the disease is colorectal carcinoma.