ADGRB3 shows high expression in the cerebellum and in hippocampal neurons where it acts as a regulator of synapse density and where its knockdown leads to significant impairment in dendrite morphogenesis in mouse models, whereas in a human study the clinical spectrum in patients with biallelic intragenic duplication in ADGRB3 also included, among other symptoms, anxiety and mood instability, which are associated with hippocampal dysfunction32,38,39 and which is specifically in line with our findings that variation in this gene shows association of anxious affective temperament. Here, ADGRB3 is linked to Anxiety.