RHOBTB2 and acute promyelocytic leukemia: The box plots showed that RHOBTB2 was remarkably increased in FAB subtypes M0, M1, M2, M4, and M5 compared to that in M3 (also known as acute promyelocytic leukemia (APL)), which has a higher degree of differentiation (P < 0.001 for M0 vs. M3, M1 vs. M3, M2 vs. M3, M4 vs. M3 and M5 vs. M3, Figure 4A).