As shown in Figure 3E, the forest plots indicated that high RHOBTB2 expression, but not high RHOBTB3 expression, was strongly predictive of poor outcome in AML patients (HR = 1.581; 95% CI, 1.102–2.270; P = 0.012), independent of clinical features including age, WBC count, blast cell percentage and gene mutation status (Figure 3E). Here, RHOBTB2 is linked to acute myeloid leukemia.