GHR and Hypertension: Other GHR SNPs – rs6182, rs6180, rs6184 (minor allele frequencies 0.137, 0.387, 0.077) that are non-synonymous (amino acid changes Cys440Phe, Leu544Ile and Pro579Thr, respectively) – have been found to be associated with hypertension and elevated blood pressure in Japanese men [32].