PINK1 and Parkinson disease: In this study we aimed to analyse the biochemical changes induced by exercise in the mitochondrial proteome of the Pink1 loss of function mutant (Pink1-) Drosophila. As exercise is reported to both reduce the risk of onset and improve outcomes for Parkinson’s disease patients, we sought to characterise the biochemical changes that could underpin this improvement in our model of Parkinson’s disease.