VANGL2 and cancer: These included cancer epigenetic targets previously implicated in tumor suppressive activity such as ANXA6 [annexin A6] [20], VANGL2 [VANGL planar cell polarity protein 2] [21], BIN1 [bridging integrator 1] [22], and CREB3L1 [cAMP responsive element binding protein 3 like 1] [23].