BRAF and colorectal cancer: Other genes and pathways implicated in CIMP include SDHB [succinate dehydrogenase complex iron sulfur subunit B] in paraganglioma [7], KRAS [KRAS proto-oncogene, GTPase], and activating BRAF [B-Raf proto-oncogene, serine/threonine kinase] mutations in colorectal cancer [8, 9].