Furthermore, iPSC-CM reduce the permeability of endothelial cells by reversing the LPS-induced suppression of VE-cadherin in pulmonary endothelium and down-regulating the expression of pFAK-Tyr397 and Snail via the tissue inhibitor of metalloproteinase-1 in LPS-induced ALI [8]. The gene discussed is TIMP1; the disease is acute respiratory distress syndrome.