Furthermore, iPSC-CM reduce the permeability of endothelial cells by reversing the LPS-induced suppression of VE-cadherin in pulmonary endothelium and down-regulating the expression of pFAK-Tyr397 and Snail via the tissue inhibitor of metalloproteinase-1 in LPS-induced ALI [8]. Here, CDH5 is linked to acute respiratory distress syndrome.