TGFB1 and hepatocellular carcinoma: In the epithelial HCC cell line PLC/PRF/5 that responds to TGF-β by inducing migration but maintaining epithelial characteristics without induction of the transcriptomic EMT program [9], we recently reported that TGF-β reduces mitochondrial respiration, favoring glutamine anaplerosis, which contributes to convert the TCA cycle into a source of metabolites for biosynthetic purposes, including de novo FFA synthesis [11].