In fact, as mentioned in the introduction section, a previous study from our group proposed that TGF-β reduces mitochondrial respiration, favoring aerobic glycolysis and glutamine anaplerosis in the PLC/PRF/5 HCC cell line, which does not undergo a full EMT in response to TGF-β [11], or even may undergo epithelial–ameboid transition under determined conditions [27]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.