NOS2 and Parkinson disease: In a Wistar rat model of PD, previous administration for 4 weeks of BCP (50 mg/kg) attenuated rotenone-induced toxicity in brainstem dopaminergic neurons and controlled neuroinflammation, decreasing inducible nitric oxide synthase (iNOS), COX-2, TNFα, IL-6 and IL-1β expression [97].