Although CRT is a classical ER-resident chaperone, it has been observed outside the ER, cell surface, and extracellular compartments, and it regulates various biological processes such as uptake by dendritic cells or phagocytosis of CRT-expressing cancer cells and apoptotic cells [17,18], cell migration, and cell proliferation [19,20,21,22,23]. Here, CALR is linked to cancer.