TP53 and B-cell chronic lymphocytic leukemia: Moreover, whole exome sequencing and methylation profiling in a group of eight pre-treated patients with venetoclax-resistant del (17p) CLL identified recurrent mutations in several cancer-related genes including TP53, NOTCH1, CDKN2A/B, BRAF, CD274, SF3B1 and BTG1 [45].