In recent decades, chimeric antigen receptor (CAR) T-cell immunotherapy emerged as another exciting treatment modality for high-risk relapsed/refractory (r/r) CLL patients with resistance to other treatment modalities, complex cytogenetics, and/or TP53 abnormalities [5], who would otherwise have dismal prognoses. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.