Yet, considering the remissions induced by anti-CD19 CAR T cells in other B-cell-derived malignancies (68% to 93% in patients with acute B-lymphoblastic leukemia (ALL) [11,38], and 64 to 86% in B-cell lymphomas [12,39,40]), the efficacy of the therapy is far below expectations in the CLL scenario. The gene discussed is CD19; the disease is B-cell chronic lymphocytic leukemia.