ALDH2 and kidney disorder: As a result of multivariate regression logistic analysis for Oldest Old men, this study found nine significant factors, including six positively associated factors (genotype of rs671 (ALDH2), ALT, ALP, history of heart disease, frailty score, and history of renal disease) and three negatively associated factors (γGTP, CHE, and HDLC; Figure 5a).