BCHE and heart disorder: As a result of multivariate regression logistic analysis with these 13 factors for Oldest Old men, nine significant factors, including six positively associated factors (HDLC, smoking history, cholinesterase (CHE), years of education, γ GTP, and BMI) and three negatively associated factors (genotype of rs671 (ALDH2), alkaline phosphatase (ALP), and history of heart disease), were found (Supplementary Figure S1b).