TP53 and hepatocellular carcinoma: It has also been reported that the survival-promoting role of increased mitochondrial fission is mediated by elevated ROS production and subsequent activation of AKT, which facilitates mouse double minute 2 homolog (MDM2)-mediated degradation of TP53 and NFKappaΒ Inhibitor Alpha (NFKBIA) and the nuclear factor-κB (IκB) kinase (IKK)-mediated transcriptional activity of NFKappaB in HCC cells [65].