TP53 and hepatocellular carcinoma: From a genetic perspective, HCC cells accumulate somatic DNA alterations, including mutations in the TERT (telomerase reverse transcriptase) promoter (accounting for 60% of cases), TP53 (tumor protein 53) (30% of cases), WNT (Wingless-type MMTV integration site) signaling genes CTNNB1 (Catenin Beta 1) (30% of cases) and AXIN1 (10% of cases), and chromatin remodeling genes ARID1A (AT-Rich Interaction Domain 1A) (10% of cases) and ARID2 (AT-Rich Interaction Domain 2) (5% of cases) [13,15].