Current evidence from the AD-T2DM animal model, where scientists combined the APP/PS1 mouse model with the genetic db/db model of type 2 diabetes, highlights neuroinflammatory processes manifested by a significant increase of microglia burden in the cortex and general brain atrophy in animals of 14 weeks of age when T2DM was started, but no AD pathology was observed [42]. The gene discussed is APP; the disease is Alzheimer disease.