TGFB1 and malignant colon neoplasm: TQ (35 mg/kg/day, p.o., 3 days/week for 9 weeks) enhanced cytotoxicity of 5-fluorouracil in AOM-instigated colon cancer rats by reducing expressions of Wnt, β-catenin, NF-κB, VEGF, COX2, iNOS, and TBRAS and upregulating expressions of TGF-β1, TGF-β/RII, Smad4, DKK-1, cyclin-dependent kinase inhibitor (CDKN)1-A, and GPx [118].