In addition, continuous treatment of TQ (20 mg/kg/day, intraperitoneally, for 42 days) ameliorated D-Gal/AlCl3-induced cognitive deficit by protecting against oxidative stress, enhancing cholinergic function and increasing brain-derived neurotrophic factor (BDNF) and Bcl-2 levels [55]. This evidence concerns the gene BDNF and Cognitive impairment.