In human osteosarcoma, DK1 induces apoptosis in U2OS and MG-63 cells through the mitochondrial-dependent signaling pathway [34], and CH-5 triggers the apoptotic pathway in U2OS, MG-63, and Saos-2 cells via the modulation of transcription factors p53/Sp1 [35]. Here, TP53 is linked to osteosarcoma.