Antitumor events were promoted by the miR-34a-5p/HMGB1 axis in acute myeloid leukemia [96], cutaneous squamous cell carcinoma [72], cervical cancer, and colorectal cancers [71], and similar effects were exerted by miR-34a-3p/HMGB1 in retinoblastoma [70]. The gene discussed is HMGB1; the disease is cutaneous squamous cell carcinoma.