CALR and colorectal cancer: It was also demonstrated that the miR-27a-3p throught targeting CRT modulates MHC class I surface exposure, and that, in particular, high miR-27a-3p concomitant with low CRT expression associates with enhanced tumor growth in vivo, colorectal cancer stage, development of metastasis, and impairment of CD8+ T-cell infiltration [67].