A recent study on Alu element insertion reported that 5 of 26 (19%) patients with AR-RP with heterozygous RP1 variants located outside the hotspot region had Alu element insertion in the other alleles, suggesting that Alu element insertion might be found in the other alleles in patients with AR-RP showing only heterozygous RP1 variants [21]. Here, RP1 is linked to retinitis pigmentosa 1.