Plasma levels of IgM against the A2M824–841 unmodified peptide among patients with CAD with >70% stenosis were lower than those of HCs by 0.58-fold (p < 0.0001), patients with CAD with 30~70% stenosis were 0.66-fold (p < 0.0001) lower than HCs, and patients with CAD with <30% stenosis were 0.69-fold (p = 0.0027) lower than HCs (Supplementary Figure S2E). The gene discussed is CD40LG; the disease is coronary artery disorder.