CD40LG and coronary artery disorder: Moreover, many studies indicated that declining levels of IgM against MDA-modified proteins are associated with increasing risks of CAD; for example, Björkbacka H. et al. observed that subjects who suffered an acute coronary event had lower levels of IgM-p45 MDA (hazard ratio: 0.72) and lower levels of IgG-p210 native (hazard ratio: 0.73) [42].