TP53 and endometrial cancer: In the case of simultaneous presence (3% of endometrial cancers) of two or three molecular signatures (the so-called “multiple classifier”: MMRd/p53abn; POLEmut/p53abn; MMRd/POLEmut/p53abn; MMRd/POLEmut), it should be remembered that outcomes correspond to those predicted by the driver molecular subtype; in particular, the POLEmut signature, when characterized by a pathogenic status, prevails over the other signatures, conferring a good prognosis regardless of MMR and p53 status, while the MMRd signature prevails over the p53abn signature [89].