On the one hand, mice that received 250 mg/kg/day DCIns or 500 μg/kg/day letrozole (positive controls) modeled a PCOS-like syndrome, with cystic ovaries, high testosterone levels and low amounts of ovarian aromatase; on the other hand, mice that received 500 mg/kg/day and 1000 mg/kg/day DCIns displayed histological ovarian lesions resembling a menopausal state, with increased follicular/stromal cellularization and loss of normal follicular structure, low testosterone levels and unaltered amounts of ovarian aromatase. This evidence concerns the gene CYP19A1 and Ovarian cyst.