Recent studies evaluated the role of GDF-15 as a biomarker of myocardial fibrosis in patients with NIDCM [97], its correlations with worsening functional capacity in idiopathic dilated cardiomyopathy [98] and its role for risk stratification of arrhythmic death in NIDCM [99]. The gene discussed is GDF15; the disease is idiopathic dilated cardiomyopathy.