Surprisingly, this pro-apoptotic effect of Nucb2/nesfatin-1 is contradictory to the effect previously observed for colon and renal cell cancers, where Nucb2/nesfatin-1, through the AMPK/mTOR signaling pathways, contributed to the enhanced aggressiveness and invasiveness of these tumors [19,38]. This evidence concerns the gene NUCB2 and renal cell adenocarcinoma.