SIRT6 and Insulin resistance: In particular, two main aspects were covered by this study: (a) chemical characterization and differentiation of the most abundant phenolics by means of an integrated approach of NMR, HPLC, and spectroscopic techniques and (b) the in vitro bioactivity in endothelial models of insulin resistance and hyperglycemia and potency as SIRT1 and SIRT6 activators.