ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In the literature, some investigations have shown the relationship between this genetic variant (rs3774261) on ADIPOQ gene and obesity, metabolic syndrome, diabetes mellitus, and serum adiponectin levels [23,24], with an increased risk to present type 2 diabetes, obesity, and hypoadiponectinemia in a non-Caucasian population [24,25].