EDN1 and endothelial dysfunction: Endothelial dysfunction occurs due to an altered production of endothelial vasoactive mediators, i.e., decreased vasodilator and antiplatelet factors such as NO and prostacyclin (PGI2), and increased vasoconstrictors and prothrombotic factors such as endothelin-1 (ET-1), serotonin (5-HT) and thromboxane (TXA2) among others [3].