Ando et al. [58] suggested a novel early-stage BC screening by the combined expression of miR-21 and matrix metalloproteinase-1 (MMP-1)/CD63 in urinary exosomes; 22 patients with relatively early detected BC were enrolled for the study; two patients were in Stage 0, seven in Stage I, seven in stage II and the remaining six in Stage III. This evidence concerns the gene MMP1 and breast cancer.