PCa-derived urine exosomes being hypothesized to contain the two PCa biomarkers Prostate-specific membrane antigen (PSMA) and the PCA-specific gene marker (PCA3), these two EV components were chosen for checking the EV capacity for patients classification, with states otherwise identified by serum-PSA and tissue biopsy. The gene discussed is KLK3; the disease is posterior cortical atrophy.