Studies with other TSPO radioligands reported that TSPO expression in gliomas is predominantly related to neoplastic cells and a lack of TSPO expression in surrounding reactive astrocytes, and we note that further research using step-wise stereotactic biopsies in spatial correlation with PET is warranted to further elucidate the issue of general neuroinflammation in the presence of glioma [31,32,33]. The gene discussed is TSPO; the disease is glioma.