CDH1 and Hereditary breast cancer: The genetic counseling and testing criteria for CDH1 mutations were updated in 2019, with full criteria indications for patients with two or more documented cases of gastric cancer at any age in first- or second-degree relatives with at least once confirmed DGC, personal history of DGC before age 40 years, or personal or family history (first- or second-degree relatives) of DGC and lobular breast cancer with at least one diagnosed before the age of 50 years [6,7].