Among the oncogenic pathways altered in HCC, the WNT/b-catenin is the most frequent pathway, overstimulated by activating mutations in CTNNB1 [74] or inactivating mutations/DNA methylation in AXIN1 and in adenomatous polyposis coli gene (APC), respectively [22]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.