In normal hepatocytes undergoing hyperproliferation (HCA), CTNNB1 mutations usually occur prior to the telomerase reverse transcriptase (TERT) promoter mutations, whereas in the case of HCC development in cirrhotic liver (accounting for most of the cases), TERT promoter mutations are observed first, in pre-cancerous stages [22,60,72]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.