Focusing on evolutionary trajectories in liver cancer, Ding and colleagues [18] identified TP53, CTNNB1, and TERT mutations as founder drivers and convergent mutations in key drivers including TP53, TERT, CTNNB1, TSC2, JAK1, NOTCH1, FGFR3, ATRX, and RPS6KA3. This evidence concerns the gene TP53 and liver cancer.