Furthermore, patients with high eNAMPT levels have an overall reduced survival [186,187]; (iii) NAMPT over-expression recapitulates BRAF inhibitors resistance phenotype plasticity [188], data confirmed also by Ohanna et al. [189]; (iv) NAMPT targeting leads to NAD and ATP depletion, decreasing cell survival and reduced tumor growth in vitro and in melanoma xenografts in immunocompromised mice [186]. The gene discussed is NAMPT; the disease is melanoma.