SLC2A1 and melanoma: Over-expression of GLUT1 and MCT4 are significantly correlated with progression from primary tumor to lymph node metastasis in a cohort of patient-derived melanoma samples, suggesting that the Warburg phenotype, lactate and protons secretion, drastically alters the melanoma microenvironment, facilitating angiogenesis, promoting melanoma metastasis, and suppressing the immune system [62,63].