BRAF and melanoma: Audrito et al. extensively demonstrated the driver role of the NAMPT/NAD axis in the acquisition of resistance to BRAF inhibitors: (i) NAMPT appeared to be the master regulator of NAD biosynthesis in resistant melanoma cells, a key element involved in metabolic reprogramming [45,186]; (ii) melanoma patients, including those resistant to BRAF inhibitors, showed increased tissue and serum expression of NAMPT as compared to healthy controls or to patients with localized disease.