In our study, elevations in TNFRI, IKK-α/β phosphorylation, JNK phosphorylation, IRS1 serine-307 phosphorylation, lipid peroxidation, GSH reduction, and IL-6 expression, along with a reduction in Akt phosphorylation, were observed in the gastrocnemius muscles of stroke rats, and these alterations were alleviated by R-7050. This evidence concerns the gene IRS1 and Stroke.