Another example is Astilbin, a bioactive compound extracted from the medicinal herb Rhizoma Smilacis glabrae, which has also been shown to have the potential effect of reducing ROS and activating NRF2 (a key transcription factor in the cellular defense against oxidative or electrophilic stress), as well as inhibiting Vascular Endothelial Growth Factor (VEGF), an important factor in the maintenance of inflammation caused in psoriasis [143]. This evidence concerns the gene VEGFA and psoriasis.